Dual Specificity MAP Kinase Phosphatase activates PEPCK transcription and increases gluconeogenesis in Rat Hepatoma Cells
نویسندگان
چکیده
Haiyan Xu*, Qing Yang, Minhui Shen, Xueming Huang, Marlene Dembski, Ruth Gimeno, Louis A. Tartaglia, Rosana Kapeller and Zhidan Wu From Millennium Pharmaceuticals, Inc., Cambridge, Massachussetts 02139 Running Title: MKP-3 and gluconeogenesis Address correspondence to Zhidan Wu, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139, Phone: (617) 871-7345; Fax: (617) 8717051; E-mail: [email protected]
منابع مشابه
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
Insulin regulates the rate of expression of many hepatic genes, including PEPCK, glucose-6-phosphatase (G6Pase), and glucose-6-phosphate dehydrogenase (G6PDHase). The expression of these genes is also abnormally regulated in type 2 diabetes. We demonstrate here that treatment of hepatoma cells with 5-aminoimidazole-4-carboxamide riboside (AICAR), an agent that activates AMP-activated protein ki...
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